The coronavirus disease, 2019 (COVID-19), has led to the worst worldwide healthcare outbreak of the current century. Our knowledge on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus), the agent causing COVID-19, has dramatically increased in recent years. Further, healthcare systems are facing another outbreak due to COVID-19—long COVID or post-COVID-19 syndrome—which is the presence of long-lasting symptoms after an acute SARS-CoV-2 infection. The development of long-lasting post-COVID-19 symptoms has been called long COVID or a post-COVID-19 condition. To date, more than 100 potential long-lasting post-COVID symptoms have been potentially attributed to SARS-CoV-2. This Special Issue of Biomedicines, entitled "Latest Research in Post-COVID-19 (long COVID-19): Pathological and Treatment Studies of Sequelae and Complications”, has focused on potential gaps in our knowledge regarding the identification, timeframe, mechanisms, and treatment strategies for the management of the post-COVID-19 condition. The fourteen published papers in this Special Issue cover the following topics: 1, treatment of the post-COVID-19 condition; 2, neonatal repercussion of the SARS-CoV-2 infection; 3, risk factors of severe COVID-19; 4, phenotyping of post-COVID-19 pain; and 5, others.

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Cumulating evidence shows that lifestyle factors such as physical (in)activity, stress, poor sleep, unhealthy diet, and smoking are associated with chronic pain severity and sustainment across all age categories. A paradigm shift from a tissue- and disease-based approach towards individually tailored multimodal lifestyle interventions should lead to improved outcomes and decrease the psychological and socioeconomic burden of chronic pain. Such an approach fits well into the global move towards precision pain medicine for patients with chronic pain. For these reasons, this book is dedicated to Lifestyle and Chronic Pain.

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